Potassium Thiocyanate for Hypertension

Potassium Thiocyanate in the Treatment of Hypertension *

Ever since Pauli' first recommended thiocyanates for the treatment of hypertension almost forty years ago, the therapeutic value of these drugs has been a subject of controversy. Interest apparently declined after Ayman's pronouncement,' in 1931, that thiocyanates lacked dinical usefulness because there appeared to be an insufficient margin of safety between the hypotensive and the toxic doses....

Solvation Phenomena of Potassium Thiocyanate in Methanol–Water Mixtures

This paper reports the results of a variety of experiments carried out for understanding the solvation behavior of potassium thiocyanate in methanol–water mixtures. Electrical conductivity, speed of sound, viscosity, and FT-Raman spectra of potassium thiocyanate solutions in 5 and 10% methanol–water (w/w) mixtures were measured as functions of concentration and temperature. The conductivity and...

Potassium-Sparing Diuretics in Hypertension

A potassium thiocyanate extract vaccine prepared from Pasteurella multocida 3:A protects rabbits against homologous challenge.

Potassium thiocyanate extracts of a virulent Pasteurella multocida 3:A rabbit isolate were prepared and used as a vaccine in rabbits. The extract contained protein, carbohydrate, hyaluronic acid, lipopolysaccharide, DNA, and RNA. The protein and lipopolysaccharide profiles of the extract were similar to those of the P. multocida cell membrane. Rabbits were vaccinated intranasally (i.n.) or intr...

Serum sodium and potassium in essential hypertension.

DIFFERENCES have been noted between normotensive and hypertensive individuals in salt intake,' intracellular electrolytes,2 total body electrolytes,3 serum electrolytes,4 and the renal excretion of sodium and water.5 If changes in serum sodium concentration reflected intracelluar or metabolic alterations in electrolyte balance, an easily determined factor would be available for study of electro...